{"id":914,"date":"2019-05-11T15:29:00","date_gmt":"2019-05-11T13:29:00","guid":{"rendered":"http:\/\/leo-foundation.org.bluebird.pw\/en\/?p=914"},"modified":"2021-03-11T09:57:12","modified_gmt":"2021-03-11T08:57:12","slug":"the-leo-foundation-award-2019-region-americas","status":"publish","type":"post","link":"https:\/\/leo-foundation.org.bluebird.pw\/en\/2019\/05\/11\/the-leo-foundation-award-2019-region-americas\/","title":{"rendered":"The LEO Foundation Award 2019 – Region Americas"},"content":{"rendered":"\n
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11 May 2019<\/p>\n\n\n\n

The LEO Foundation is excited to reveal the winner of the LEO Foundation Award 2019, Region Americas – Maksim Plikus.<\/strong><\/p>\n\n\n\n

Maksim Plikus is Associate Professor at the Department of Developmental and Cell Biology, School of Biological Sciences, University of California, Irvine, USA. He receives 100,000 USD for his research in skin stem cells and regeneration.<\/p>\n\n\n\n

The LEO Foundation Award 2019 has just been presented by The LEO Foundation Chief Grant Officer, Ida Brams, at a ceremony at the SID Annual Meeting in Chicago.<\/p>\n\n\n\n

\u201cI\u2019m very proud to present the LEO Foundation Award 2019 Region Americas  to Maksim Plikus,\u201d Ida Brams smiles. \u201cHe is such a brilliant researcher and a great storyteller \u2013 congrats Max!\u201d<\/p>\n\n\n\n

A major direction of Maksim Plikus\u2019s reseasrch aims to understand how skin uses selforganization to efficiently manage its stem cells. Among other things, he has discovered that thousands of hair follicles rely on distant signal-producing cells to coordinate their collective regeneration over the entire skin.<\/p>\n\n\n\n

\u201cIndeed, I am very excited and honored to be the recipient of this prestigious LEO Foundation Award,\u201d says Maksim Plikus.<\/p>\n\n\n\n

The Global Review panel was very excited about Maksim Plikus and said among other things:<\/p>\n\n\n\n

“Max has innovative research ideas and the scientific results obtained from his work have significant translational value”<\/p>\n\n\n\n

“Max\u2019s research is highly original and shows incredible vision \u2013 and his work is already having a major impact on dermatology”<\/p>\n\n\n\n

“Max\u2019s research challenges paradigms and he shows potential to become a leader in the field”<\/p>\n\n\n\n

“Max\u2019s work is highly innovative, exploring new frontiers with high-risk high-reward ideas \u2013 and his future career will be incredible”<\/p>\n\n\n\n

Learn more about Maksim Plikus<\/a><\/p>\n\n\n\n

About the award<\/a><\/p>\n\n\n\n

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Portrait of Maksim Plikus and his skin research – The exciting hair biology<\/h3>\n\n\n\n

\u201cSkin is a very large and diverse organ with many regional differences and repetitive elements, such as hair follicles. It is very much like a complex landscape,\u201d explains Maksim Plikus.<\/p>\n\n\n\n

\u201cTo truly understand how skin works, it is not sufficient to just study its small parts. Simultaneously studying behaviors of its many parts is important. My research aims at that,\u201d says Maks, who is focusing on cyclic growth of hair follicles. He finds hair biology very exciting:<\/p>\n\n\n\n

\u201cI study how thousands of hair follicles coordinate their growth activities with one another. Hair follicles actively communicate with one another and the decision to either grow or remain dormant is achieved by each hair follicle based on the cumulative long-range signaling input they receive from all their neighbors.\u201d<\/p>\n\n\n\n

Signaling crosstalk that hair follicles engage in is not limited to other hair follicles, but also includes non-hair follicle cell types. Prominently, hair follicles share signaling and co-regulate each other\u2019s activities with skin adipose tissue.<\/p>\n\n\n\n

Recently, Maksim Plikus showed that hair follicles in the center of early scar tissue can signal to fibroblasts and induce their conversion into fat cells. As the result, new adipose tissue can regenerate within scars.<\/p>\n\n\n\n

What is unique about it?<\/strong><\/p>\n\n\n\n

\u201cThe scale at which we study skin \u2013 across large distances, and even across the entire skin \u2013 is fairly unique to our research,\u201d explains Maks and continues:<\/p>\n\n\n\n

\u201cIn our studies we actively incorporate mathematical modelling approaches. Large-scale skin phenomena that we study often have to do with patterns, and computational approaches are particularly well-suited for studying pattern-formation. We use mathematical models to predict candidate mechanisms of pattern-forming phenomena. We then use these predictions and test them experimentally.\u201d<\/p>\n\n\n\n

Such interdisciplinary approach can be highly successful as the tool for scientific exploration, and the Plikus group actively employ it in a number of both past and present projects.<\/p>\n\n\n\n

The skin is a fantastic model<\/strong><\/p>\n\n\n\n

Situated at the interface with the external environment, skin has evolved to have robust regenerative responses to be able to efficiently repair itself.<\/p>\n\n\n\n

\u201cFor this reason,\u201d Maks says, \u201cthe skin is a fantastic model system for studying natural limits of tissue regeneration and for identifying regeneration promoting mechanisms,\u201d and proclaims:<\/p>\n\n\n\n

\u201cDiscoveries made in skin can ultimately be translated to organs, where regenerative responses are less efficient.\u201d<\/p>\n\n\n\n

Where can the research of Maksim Plikus lead to?<\/strong><\/p>\n\n\n\n

Regenerative responses can lead to novel strategies for the Regenerative Medicine, the ones that are based on enhancing endogenous regeneration-stimulating mechanisms within tissues and organs.<\/p>\n\n\n\n

\u201cEndogenous regenerative abilities of human skin are limited as compared to other animal model organisms and, often, insufficient to achieve complete healing,\u201d says Maksim Plikus and continues:<\/p>\n\n\n\n

\u201cNew regeneration-promoting signals that our research aims to identify in model organisms can potentially be translatable to humans. For instance, our work on skin wound healing promises new strategies for regenerating adipose tissue in scars, which clinically is a highly desirable outcome.<\/p>\n\n\n\n

Inspiring mentors<\/strong><\/p>\n\n\n\n

Maksim Plikus has always been inspired by nature as well as the classic scientific literature. But his fascination of the skin biology came by working in the laboratories of two leading scientists in the field:<\/p>\n\n\n\n

\u201cI had the honor of working with Dr. Cheng-Ming Chuong and Dr. George Cotsarelis. Both of them made significant and impactful discoveries in Developmental and Stem Cell Biology of the skin,\u201d tells Maks.<\/p>\n\n\n\n

\u201cIn both labs, I was given an opportunity to develop projects that were based on very novel and fascinating observations, that could not be explained with conventional knowledge at the time. Working on these projects opened my eyes to many other fascinating aspects of skin biology that still await answers\u201d.<\/p>\n\n\n\n

Lemonade and paddleboard<\/strong><\/p>\n\n\n\n

When Maks is not looking for new answers in skin biology, he does enjoy other aspects of nature.<\/p>\n\n\n\n

\u201cLiving close to the Pacific Ocean, some of my most favorite activities are open-water diving and stand-up paddle boarding. On a good day, you are almost guaranteed to encounter a pod of dolphins or seals while padding,\u201d he smiles.<\/p>\n\n\n\n

What also makes him smile, is his two-year old daughter who is already very helpful watering the household\u2019s two orange trees and a lemon tree.<\/p>\n\n\n\n

\u201cWhile we can make lemonades year round, orange season is however only in the winter months.\u201d<\/p>\n\n\n\n

The very early stages<\/strong><\/p>\n\n\n\n

Do you want to know more about the very early stages of Maksim Plikus\u2019 research, then have a\u00a0look at this video from the LEO Foundation Award Ceremony<\/a> at the SID meeting in Chicago in May 2019. Here, Maks explains the very early stages of his fascination of science when he did organic farming with his sister (watch from 5:05 \u2013 11:11)<\/p>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"

11 May 2019 The LEO Foundation is excited to reveal the winner of the LEO Foundation Award 2019, Region Americas – Maksim Plikus. Maksim Plikus is Associate Professor at the Department of Developmental and Cell Biology, School of Biological Sciences, University of California, Irvine, USA. He receives 100,000 USD for his research in skin stem … Continued<\/a><\/p>\n","protected":false},"author":4,"featured_media":916,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-914","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"acf":[],"yoast_head":"\nThe LEO Foundation Award 2019 - Region Americas - LEO Foundation<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The LEO Foundation Award 2019 - Region Americas - LEO Foundation\" \/>\n<meta property=\"og:description\" content=\"11 May 2019 The LEO Foundation is excited to reveal the winner of the LEO Foundation Award 2019, Region Americas – Maksim Plikus. 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